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Nosso Pipeline

Nós visamos abordar os principais impulsionadores do câncer e transformar tumores frios em quentes, com uma diversa gama de modos de ação e combinações inteligentes

Última fase de desenvolvimento (a partir de junho de 2024)

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Saiba mais
Immuno-oncology

DLL3/CD3 T-cell engager

Phase II: SCLC / other NECs
Phase I: SCLC / NECs expressing DLL3
Saiba mais
Combination

zongertinib + trastuzumab deruxtecan (T-DXd) or trastuzumab emtansine (T-DM1)

Phase I: Solid tumors
 
Combination

DLL3/CD3 T-cell engager + standard of care

Phase I: ES-SCLC
 
Combination

B7-H6/CD3 T-cell engager + ezabenlimab

Phase I: Solid tumors
 
Combination

CD137 FAP bispecific agonist antibody + ezabenlimab

Phase I: Solid tumors
 
Combination

SIRPα antagonist (BI 765063) + ezabenlimab

Phase I: Solid tumors
 
Combination

SIRPα antagonist (BI 770371) + ezabenlimab

Phase I: Solid tumors
 
Combination

VSV-GP + ezabenlimab

Phase I: Solid tumors
 
Combination

KISIMA™ cancer vaccine (ATP150/ATP152) and VSV-GP154 + ezabenlimab

Phase I: PDAC
 
Combination

2nd generation STING agonist + ezabenlimab

Phase I: Solid tumors
 
Download Pipeline PDF

  1. ClinicalTrials.gov. NCT06324357. https://clinicaltrials.gov/study/NCT06324357 (Accessed: June 2024)
  2. ClinicalTrials.gov. NCT04886804. https://clinicaltrials.gov/study/NCT04886804 (Accessed: June 2024)
  3. ClinicalTrials.gov. NCT06151574. https://clinicaltrials.gov/study/NCT06151574 (Accessed: June 2024)
  4. ClinicalTrials.gov. NCT05376800. https://clinicaltrials.gov/study/NCT05376800 (Accessed: June 2024)
  5. ClinicalTrials.gov. NCT05512377. https://clinicaltrials.gov/study/NCT05512377 (Accessed: June 2024)
  6. ClinicalTrials.gov. NCT06058793. https://clinicaltrials.gov/study/NCT06058793 (Accessed: June 2024)
  7. ClinicalTrials.gov. NCT04429087. https://clinicaltrials.gov/study/NCT04429087 (Accessed: June 2024)
  8. ClinicalTrials.gov. NCT05882058. https://clinicaltrials.gov/study/NCT05882058 (Accessed: June 2024)
  9. ClinicalTrials.gov. NCT04752215. https://clinicaltrials.gov/study/NCT04752215 (Accessed: June 2024)
  10. ClinicalTrials.gov. NCT04958239. https://clinicaltrials.gov/study/NCT04958239 (Accessed: June 2024)
  11. ClinicalTrials.gov. NCT05068102. https://clinicaltrials.gov/study/NCT05068102 (Accessed: June 2024)
  12. ClinicalTrials.gov. NCT05327946. https://clinicaltrials.gov/study/NCT05327946 (Accessed: June 2024)
  13. ClinicalTrials.gov. NCT05155332. https://clinicaltrials.gov/study/NCT05155332 (Accessed: June 2024)
  14. ClinicalTrials.gov. NCT05839600. https://clinicaltrials.gov/study/NCT05839600 (Accessed: June 2024)
  15. ClinicalTrials.gov. NCT05846516. https://clinicaltrials.gov/study/NCT05846516 (Accessed: June 2024)
  16. ClinicalTrials.gov. NCT05471856. https://clinicaltrials.gov/study/NCT05471856 (Accessed: June 2024)
  17. ClinicalTrials.gov. NCT06056024. https://clinicaltrials.gov/study/NCT06056024 (Accessed: June 2024)
  18. ClinicalTrials.gov. NCT06324357. https://clinicaltrials.gov/study/NCT06324357 (Accessed: June 2024)
  19. ClinicalTrials.gov. NCT05879978. http://clinicaltrials.gov/study/NCT05879978 (Accessed: June 2024)
  20. ClinicalTrials.gov. NCT06132113. http://clinicaltrials.gov/study/NCT06132113 (Accessed: June 2024)
  21. ClinicalTrials.gov. NCT06077500. https://clinicaltrials.gov/study/NCT06077500 (Accessed: June 2024)
  22. ClinicalTrials.gov. NCT05990738. http://clinicaltrials.gov/study/NCT05990738 (Accessed: June 2024)

BTC, biliary tract cancer; CD, cluster of differentiation; CRC, colorectal cancer; DDLPS, dedifferentiated liposarcoma; DLL3, Delta-like 3; FAP, fibroblast activation protein; GBM, glioblastoma; GEJ, gastroesophageal junction; GI, gastrointestinal; GP, glycoprotein; HER2, human epidermal growth factor receptor 2; MDM2, murine double minute 2 protein; NEC, neuroendocrine carcinoma; NSCLC, non-small-cell lung cancer; SCLC, small-cell lung cancer; SIRPα, signal-regulatory protein alpha; STING, small molecule agonist of the stimulator of interferon genes; TKI, tyrosine kinase inhibitor; VSV, vesicular stomatitis virus.